Gary Eichenbaum | Preclinical Development Leader/Research Fellow
J&J Pharmaceutical R&D, LLC

Gary Eichenbaum, Preclinical Development Leader/Research Fellow, J&J Pharmaceutical R&D, LLC

Dr. Eichenbaum joined Johnson & Johnson Pharmaceutical R&D, LLC (J&J) in 2002. He is a Preclinical Development Leader/Research Fellow in the department of Drug Safety Sciences. He serves on cross-functional compound development teams and is responsible for directing the Toxicology and DMPK research for early and late development programs including the conduct of studies, writing and filing of regulatory submissions and performing due diligence on in-licensing candidates. Previous roles within J&J have included: head of the US toxicokinetics group and head of a research team at ALZA that was focused on the application of controlled-release drug delivery technologies to differentiate, rescue or reposition NME’s. Prior to joining J&J, Dr. Eichenbaum co-founded and was on the senior leadership team of a small biotechnology company called ChemCodes Inc. (spin-out from GlaxoWellcome), which applied its high-throughput chemistry platform to the discovery and development of NME candidates. His primary scientific interests include safety assessment, pharmacokinetics, elucidation of mechanisms of toxicity, and drug delivery. Dr. Eichenbaum has authored more than 25 publications/patent applications. He holds a B.S. in Bioengineering from the University of Pennsylvania, a B.S. in Technology Management from the Wharton School, and M.S. and Ph.D. degrees in Biomaterials/Cell & Biosurface Engineering from Duke University.

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Appearances at this years' conference:

Thursday 24 May 2012- Day Two


@ 14.30
Approaches and Considerations in the Cardiovascular Safety Assessment of Compounds with QT Effects and Mixed Ion Channel Activities

  • For drugs that increase the QT interval, it is now well recognized that potency at the hERG channel coupled with QT prolongation alone are not predictive of cardiac arrhythmia potential and that offsetting activity of a drug at the sodium and calcium channels must also be considered
  • Significant progress has been made in developing nonclinical models for evaluating EAD and biomarkers for TdP potential that go beyond only looking at in vitro hERG and in vivo QT effects
  • Approaches and considerations for evaluating the cardiovascular safety of drugs with mixed ion channel effects will be discussed and a case study example related to the assessment of several fluoroquinolone antibacterial agents will be presented

  • › Gary Eichenbaum, Preclinical Development Leader/Research Fellow, J&J Pharmaceutical R&D, LLC
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